Expression of leukocyte immunoglobulin-like receptor subfamily B expression on immune cells in hepatocellular carcinoma

J Fan, J Li, J Han, Y Zhang, A Gu, F Song, J Duan… - Molecular …, 2021 - Elsevier
J Fan, J Li, J Han, Y Zhang, A Gu, F Song, J Duan, D Yin, L Wang, Y Yi
Molecular Immunology, 2021•Elsevier
Highlights•We assessed LILRB family expression on immune cells from peripheral blood
and tumor tissues in HCC patients.•The expression of LILRB1, LILRB2 and LILRB3 in
granulocytes from peripheral blood were increased in HCC patients compared with healthy
donors. LILRB5 in NK cells and NKT cells from HCC blood were expressed higher
compared with healthy donorsblood.•CD14+ CD16+ monocyte subsets in blood of HCC
patients expressed increased LILRB1 and LILRB4 than that in healthy donors. CD14+ …
Highlights
  • We assessed LILRB family expression on immune cells from peripheral blood and tumor tissues in HCC patients.
  • The expression of LILRB1, LILRB2 and LILRB3 in granulocytes from peripheral blood were increased in HCC patients compared with healthy donors. LILRB5 in NK cells and NKT cells from HCC blood were expressed higher compared with healthy donorsblood.
  • CD14+ CD16+ monocyte subsets in blood of HCC patients expressed increased LILRB1 and LILRB4 than that in healthy donors. CD14+ CD16− monocyte subsets in blood of HCC patients expressed increased LILRB3 than that in healthy donors. Compared to corresponding TFL, LILRB3, LILRB4 and LILRB5 were expressed enhanced in TAMs from HCC tumors. LILRB1 expressed on the B cells both in the blood and tumor had significantly increased compared with healthy donors or corresponding TFL.
  • The percentage of LILRB1 expressed on MDSC from HCC peripheral blood and tumors was lower than that from healthy donors and corresponding TFL.
  • The specific increasing expression of LILRB on immune cells may regulate innate and adaptive immune and impact on HCC progression.
Elsevier
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